ea0029s62.2 | Early Development and Treatment of PCOS | ICEECE2012
de Zegher F.
, Ibanez L.
PCOS (defined by NIH, Rotterdam or AES criteria) is traditionally viewed as an ovarian disorder that appears in adolescence and may lead to metabolic complications in adulthood. Emerging evidence, however, indicates that PCOS is primarily a disorder of adipose-tissue hyperexpansion that may originate in early life, develop across childhood and puberty, and advance into end-stage disease (including ovulatory dysfunction and ovarian androgen excess) by adolescence. Prepubertal m...